Presentation by Joe St. Sauver (Internet2 and University of Oregon), focused on client cert deployment models, but many of these points will resonate with, and be applicable to, other multi-factor approaches. Original can be found at:
http://pages.uoregon.edu/joe/client-cert-models/

Some key points (slide titles) from this pdf of a slide presentation at the Internet2 Joint Techs meeting in January 2012: